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ORIGINAL ARTICLE
Year : 2013  |  Volume : 1  |  Issue : 3  |  Page : 129-134

Evaluation of selected trace elements in male type 2 diabetic patients in Nnewi, south eastern Nigeria


1 Department of Chemical Pathology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria
2 Department of Human Biochemistry, Faculty of Basic Medical Sciences; Department of Chemical Pathology, Faculty of Medicine, Nnamdi Azikiwe University, Nnewi Campus, Nigeria
3 Department of Chemical Pathology, Faculty of Medicine, Nnamdi Azikiwe University, Nnewi Campus, Nigeria
4 Department of Internal Medicine, Faculty of Medicine, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Nigeria

Correspondence Address:
Christian Ejike Onah
Department of Chemical Pathology, Nnamdi Azikiwe University Teaching Hospital, Nnewi
Nigeria
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DOI: 10.4103/1658-600X.120848

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Background: There is accumulating evidence that the metabolism of several trace elements is altered in type 2 diabetic patients. Aims: We, therefore, investigated the levels of some of the trace elements in serum of male type 2 diabetic patients with a view to establishing their metabolic status in these subjects. Materials and Methods: One hundred and twenty-five male type 2 diabetic subjects and 50 apparently healthy non-diabetic male individuals within the age range of 32 - 70 years were recruited for this study. Fasting plasma glucose (FPG), trace elements (zinc, selenium, manganese and chromium), and body mass index (BMI) were determined. Results: The mean levels of Zn, Mn, Se and Cr were significantly lower in serum of type 2 diabetic patients when compared with non-diabetic controls (P < 0.001). Expectedly, the mean level of FPG in diabetic subjects was significantly higher when compared with the healthy controls (P < 0.001) however, there was no significant different in the level of BMI (P > 0.05). This study also observed a significant negative correlation between the serum levels of Trace Elements (Zn, Se, Cr and Mn) and the FPG in diabetic subjects. Conclusion: Consequently, the decrease in levels of trace elements may play a role in pathogenesis of diabetes mellitus considering their roles in glucose metabolism. Therefore, proper dietary control and mineral supplementation is advised.


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